Interactions between the top 50 pathways from 659 Autistic Spectrum Disorder (ASD) genes are displayed. Pathways are grouped as Disease Pathways (left column; purple) and Functional Pathways (right column; green). The color of each node inside the groupings represents the p-value of that pathway (p-value bar at lower left). The size of each node represents the number of ASD genes in that pathways. From Figure 2 in “Pathway Network Analysis for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Convergence upon MAPK and Calcium Signalling” published April 7, 2016 in PLOS One.